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Дата: Пятница, 28.02.2014, 10:39 | Сообщение # 316

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Дата: Пятница, 28.02.2014, 18:04 | Сообщение # 319

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Дата: Пятница, 14.03.2014, 12:00 | Сообщение # 320

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Ciclosporin (INN/BAN) (pronounced /?sa?kl??sp?r?n/);[1] cyclosporine (USAN); cyclosporin (antediluvian PROHIBITION); or ciclosporin A, cyclosporine A, or cyclosporin A (again shortened to CsA) is an immunosuppressant remedy widely cast-off in mouthpiece transplantation to ward rejection. It reduces the activity of the vaccinated routine during interfering with the activity and growth of T cells.[2][3] It was initially out-of-the-way from the fungus Tolypocladium inflatum (Beauveria nivea), found in a soil sample obtained in 1969 from Hardangervidda, Norway, nearby Dr. Hans Peter Frey, a Sandoz biologist.[4] Most peptides are synthesized by means of ribosomes, but ciclosporin is a cyclic nonribosomal peptide of 11 amino acids and contains a single D-amino acid, which are once in a blue moon encountered in nature.[5]
Medical uses
The immunosuppressive power of ciclosporin was discovered on 31 January 1972 by way of employees of Sandoz (now Novartis) in Basel, Switzerland, in a screening check-up on protected halting designed and implemented by means of Hartmann F. St?helin, M.D. The achievement of ciclosporin in preventing organ cold shoulder was shown in kidney transplants past R.Y. Calne and colleagues at the University of Cambridge,[6] and in liver transplants performed by Dr. Thomas Starzl at the University of Pittsburgh Hospital. The maiden patient, on 9 Stride 1980, was a 28-year-old woman.[7] Ciclosporin was later on approved for the purpose make use of in 1983. Since then, it has been cast-off to forbid and prescribe for graft-versus-host reactions in bone-marrow transplantation and to thwart dismissal of kidney, pluck, and liver transplants.[8]
In addition to transplants, ciclosporin is also used in psoriasis, unsympathetic atopic dermatitis, pyoderma gangrenosum, persistent autoimmune urticaria, and, now, in rheumatoid arthritis and related diseases, although it is only adapted to in wicked cases. It is commonly prescribed in the US as an ophthalmic emulsion in place of the treatment of dreary eyes.[8] It has been investigated as a replacement for consume in sundry other autoimmune disorders, and is every once in a while prescribed in veterinary cases, uniquely in remotest cases of immune-mediated hemolytic anemia. Inhaled ciclosporin has been investigated to treat asthma and is being intentional as a shield cure representing lasting rebuff of the lungs. Ciclosporin has also been reach-me-down to help treat patients with sharp onerous ulcerative colitis that do not rejoin to treatment with steroids.[9] This drug is also worn as a treatment of seat or medial uveitis with noninfective etiology. Ciclosporin is a drug currently used to experimentally handle cardiac hypertrophy[10][11] (an prolong in cell mass).
Ciclosporin has been investigated as a reasonable neuroprotective emissary in conditions such as traumatic perspicacity injury, and has been shown in beastlike experiments to curtail perception mutilation associated with injury.[12] Ciclosporin blocks the formation of the mitochondrial permeability evolution pore, which has been organize to issue much of the cost associated with head maltreatment and neurodegenerative diseases. Ciclosporin's neuroprotective properties were word go discovered in the initial 1990s when two researchers (Eskil Elmér and Hiroyuki Uchino) were conducting experiments in stall transplantation. An unintended conclusion was that CsA was strongly neuroprotective when it crossed the blood–brain barrier.[13] This nevertheless handle of mitochondrial breaking up through the opening of the MPT pore is implicated in making traumatic intellect injuries much worse.[14] Cyclosporine is currently in a phase II/III (adaptive) clinical reflect on in Europe to judge its know-how to ameliorate neuronal cellular bill in traumatizing genius injury. This multi-center about is being organized by NeuroVive Pharma and the European Perceptiveness Offence Consortium using NeuroVive's formulation of cyclosporine called NeuroSTAT?. [15]

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Дата: Среда, 19.03.2014, 03:37 | Сообщение # 321

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Дата: Понедельник, 28.04.2014, 17:47 | Сообщение # 322

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Дата: Вторник, 20.05.2014, 14:49 | Сообщение # 323

Группа: Гости